Acs designed and supplied a hurricane cyclone for hovione, a multinational portuguese company. Solid dispersion is defined as the dispersion of one or more active ingredients in an inert excipient or matrix carrier, where the active ingredients could exist in finely crystalline, solubilized or amorphous state sareen et al. The plan over the next three years is to continue investing, especially in portugal, where the firm will add 165 m 3 of chemical synthesis capacity, a spray dryer building, and a 1,200m 2 analytical lab. The inert loop is the perfect accessory to enable the mini spray dryer b290 and the nano spray dryer b90 to handle organic solvents safely. Spray drying systems brochure spray dryers, spray dryer. Jul 22, 2010 hovione cork, in loughbeg, ireland, is the newest site in the hovione group. Development of timely, meaningful, and reliable measurements. The guided tour will include a visit of the spray dryer building where pilot, small and full commercial scale equipment can be seen. Atomization by kinetic energy 2, 5 liquid feedstock and compressed air or steam are combined in a twofluid nozzle figure 4. A spray dryer attached to a vibrating fluid bed system, as shown in figure 1,spray comprises the twostage drying.
P asti lha of hovione describe the latest technologies. Revealing facts behind spray dried solid dispersion. Pharmaceutical spray dryer at hovione 82 kgh at 70. Spray drying is used in a multitude of pharmaceutical applications. Jul 06, 2015 hovione is adding new spray drying capacity at its facility in loures, portugal, the company has announced.
Finally, the most promising formulation was scaled up to a pilot scale spray dryer. To handle high potency active pharmaceutical ingredients. Hovione installs largescale spray drying unit epm magazine. Hovione installs a new large scale spray drying unit hovione. Spraydrying technology in particular is highlighted as a highly favourable, scalable manufacturing technique for inhalable. It is a continuous process that converts, in a single step, a liquid feed into a powder and is an ideal process when precise attributes such as particle size, morphology and stability are required. Spray drying over the last 15 years, the technology has been used for the production of solid dispersions and is the fastest growing platform to overcome the solubility issues related to oral drugs, it is also relevant to inhalable particles, specialty excipients and for the isolation of thermally labile products. Special attention is given to the selection of right scale of spray dryer for any given processes and product demands, and also to the ancillary equipment. Liz kearney will outline the key issues relating to spray drying process design. The impressive features of the spray dryer include its efficient performance with very short setup times, an effective integrated nozzle cleaning mechanism and a high degree.
Moreover the production control room and the analytical labs will be part of the guided tour. Sds,provides expert technology for all spray drying applica tions. Air, supplied by a compressor is passed through an air dryer and a filter to. Pdf spray drying performance of a laboratory spray dryer. Spray drying is a method of producing a dry powder from a liquid or slurry by rapidly drying with a hot gas. Process optimization and upscaling of spraydried drugamino. A spray dryer attached to a vibrating fluid bed system, as shown in figure 1, spray comprises the twostage drying. Pharmaceutical particle engineering via spray drying. Apis and innovative services to the pharmaceutical industry. The spray drying method includes use of a primary drying chamber and a secondary drying apparatus which includes tubing having a length sufficient to increase the contact time between the drying gas and the dropletsparticles to dry the particles to the extent desired, at a drying rate and temperature which would be too low. The asepticsd spray dryer is perfect for the production of sterile pharmaceutical products such as vaccines, antibiotics and other products requiring aseptic conditions. Sds also offers a pressure nozzlefor use in spray dryers for those interested in lower costs.
Hovione hosts a handson spray drying session in its site in loures workshop is fully booked. Carrierfree formulations typically include api embedded in an excipient matrix and the whole particle is precisely engineered for stabilizing and successfully aerosolize and deliver the api to the lungs. The new unit will add additional capacity to the spray drying facilities at hovione. The mini spray dryer b290 is the laboratory equipment of your choice for the quick and gentle drying to powder of liquid end products. The asepticsd spray dryer is perfect for the production of sterile pharmaceutical products such as vaccines, antibiotics and. Heat and mass transfer study in the spray drying of tomato. Tray drying was applied for 48 h in a 30 c oven under vacuum, after an initial nitrogen sweep. The new largescale commercial facility is expected to be fully operational by march 2016. This invention also comprises an improved spray dryer for carrying out the above. A largescale spray drying unit specifically designed to handle high potency apis and for use with a wide variety of organic solvent systems is to be installed at hoviones new spray drying facility in loures, portugal. Spray dryer 500kghr water evaporation 570kw gas required in winter conditions 0c 570kw 10. Multinozzle spray dryer, method for scaleup of spray.
Hovione announced that it is installing a new largescale spraydrying unit in loures, portugal. A full range of cgmp spray drying facilities operating at laboratory, pilot and industrial scale have been installed at hoviones active pharmaceutical ingredient api manufacturing plant in loures, portugal, and are currently being installed at the companys technology transfer centre in new jersey, usa. The company says that the new spray dryer, which is designed with the ability to handle highly. For that purpose several spray dryers are available at hovione. The plan over the next three years is to continue investing, especially in portugal, where the firm will add 165 m 3 of chemical synthesis capacity, a spraydryer building, and. It includes background information on the current sda production and use statistics, characterization data on sda material reported in the literature, an. Fatom and tout were varied to observe the effect of the droplet size and the drying kineticsef.
The use of colloidal silica can minimize the electrostatic charge generation between powders with the spray dryer wall, leading to increased yield as well as improved flow property of powder. Wide ranges of spray dryer designs are available to meet various product specifications. Schematic representation of spray dryer layout fig. Installation will be carried out in compliance with quality and safety standards. In the spray dryer the liquid to be driedis atomised into the good droplets, that are tossed radially into a relocating stream of warm gas. The wide ranges of applications include industrial chemicals, flavorings, ceramics, pigments, dyestuffs, deter. Hovione is capable to manufacture spray dried material under cgmp conditions. Currently, hovione has spray drying facilities in portugal, ireland and the u.
A consistent particle size distribution is a reason for spray drying some industrial products such as catalysts. For example, for a single nozzle typical of a spray dryer sd1 with a gas flow rate of approximately 80 kgh 4 nozzles may be used for a spray dryer sd2 with approximately 360 kgh of drying gas, or 8 nozzles may be used for a spray dryer sd3 with approximately 650 kgh of drying gasfig. There are four fundamental steps involved in spray drying broadhead et al. Used gea niro spray tower spray dryer, plant size 80, 304 stainless steel, vertical. He is a cit marine engineering graduate who has worked in bp, esi technologies and for 15 years at. Up to 25% energy saving technical data and without heat recovery and with heat recovery spray drying with direct heating no scale f.
Hovione cork, in loughbeg, ireland, is the newest site in the hovione group. Doug hecker, responsible for business development within the particle design business pdb told inpharmatechnologist that. In this three days conference dedicated to spray drying solutions, on the last day attendees have the opportunity to take advantage of an exclusive handson training. Spray drying of pharmaceuticals institution of engineers. The company says that the new spray dryer, which is designed with the ability to handle highly potent apis, will be fully operational by march 2016. Purchased from pfizer this year, and officially opened by hovione in april 2009, the cork site is an active pharmaceutical ingredient api plant comprising two main api production buildings and a spray dryer building. Process optimization and upscaling of spraydried drug. Spray dryers utilize either an open cycle spray dryer system, closed cycle spray drying system, semiclosed spray drying system or an aseptic spray drying system. Hovione adds largescale spraydrying unit pharmaceutical. Nov 28, 2007 the evaporation of a solution droplet in a spray dryer is a coupled heat and mass transport problem.
Spray drying is one of the most remarkable technologies currently to be applied to pharmaceuticals. Spray drying technology for better api crystals the application of new techniques in spray dr ying of final pr od uct gives excellent contr ol of par ticle size in api pr oduction. A spray dryer is composed of a feed pump, atomizer, air heating unit, air dispenser, drying chamber and also systems for exhaust air cleansing and also powder recoveryseparator. Spray drying is a transformation of feed from a fluid state into a dried particulate form by spraying the feed into a hot drying medium. Gmp certification programme certified technical operations. The main aim of drying by this method in pharmaceutical. Solid dispersion consists of two or more than two components, generally a carrier polymer and drug.
Aseptic spray drying is a perfect, cost effective alternative to aseptic lyophlization for a number of products, adding that the move is a natural expansion of hoviones particle design business. A full range of cgmp spray drying facilities operating at laboratory, pilot and industrial scale have been installed at hovione s active pharmaceutical ingredient api manufacturing plant in loures, portugal, and are currently being installed at the companys technology transfer centre in new jersey, usa. In this method, agglomerates arepreserved at quality productthe exit of the spray chamber and, thus, feedinto the vibrofluidized bed system where theyare gently dried and cooled. Afterwards, a secondary tray drying step was applied as a customary industrial procedure to ensure that the solvent residues were at a suf. Area a spray dryer spray drying valparaiso, indiana. Spray drying performance of a laboratory spray dryer for tomato powder preparation article pdf available in drying technology no. A schematic diagram of a single stage spray dryer spray drying is a mostly convective drying process. Heat and mass transfer study in the spray drying of tomato juice. This invention relates to a method of minimizing the deposit of products on the cylinder wall and their back eddying into the high temperature zone through introducing tangential air currents from the inlets arranged around the discharge end of the cylinder of spray dryer so as to swirl within said cylinder. Spray dried suspensions of dextran microspheres were investigated in the context of nasal drug delivery, preformed microcapsules were spray dried to encapsulate phase change materials, and dispersions of porous and nonporous silica micro and nanoparticles were spray dried in combination with indomethacin, tolbutamide, and simvastatin. Spray drying is a continuous process that can be used for multiple applications. The cork site is important as spray drying is currently employed by hovione to manipulate the physical attributes of particles in a controlled manner in three approved commercial apis and in dozens of other apis in various phases of development. Operating close to these boundaries requires wellcontrolled critical process parameters and critical product attributes.
Oct 26, 2009 doug hecker, responsible for business development within the particle design business pdb told inpharmatechnologist that. Moreover, porous silica also works as adsorbents which gives more surface area and plays a significant role in solubility enhancement mahajan et al. The spray drying process itself consists of the following steps. For decades, spray drying has been applied for powder production by the pharmaceutical industry also under aseptic conditions. This new stateoftheart unit is specifically designed to handle high potency apis and a wide variety of organic solvent systems. The unit, which will increase hoviones spraydrying capacity, is the first phase of a broad expansion program to widen the companys offerings and meet customers needs. Buchi labortechnik ag training papers spray drying 3 2.
Spray dryer system in operation how it works youtube. Loures, portugal, 23rd october, 2009 hovione announced today that it has acquired an aseptic spraydrying production line, vial filling and back up utilities from acusphere, a company located in boston. The process engineers at sds have the experience it takes for the successful operation of your new spray dryer. Further details of spray drying technology and systems can be found in the report by wisniewski 2014. Oct 28, 2014 spray drying is one of the most remarkable technologies currently to be applied to pharmaceuticals. Applying hovione s strong expertise in spray drying technology we are able to offer a wellestablished carrierfree formulation in a single spray drying step. Mini spray dryer b290 technical data sheet the mini spray dryer b290 is the world leading laboratory scale spray dryer since many years. Submit a quote for this spray dryer or call 6303502200 for more information. Spray drying is used in a multitude of pharmaceutical applications and is often the first technique used to enable poorly soluble oral drugs, to isolate. Spray drying solutions for the pharmaceutical industry. Spray dryers have a major role in the thermal energy costs of the tile manufacturing process. The process is driven by the difference between the vapor pressure of the solvents and their partial pressure in the gas phase. Micheal donnellan production manager and technical lead at the hovione spray drying facility in ringaskiddy.
P rocess d evelopm ent spray drying technology for. It has few moving parts and careful select ion o f various co mponents can result in a system. The impressive features of the spray dryer include its efficient performance with very short setup times, an effective integrated nozzle clea ning mechanism and a high degree. Hovione is adding new spray drying capacity at its facility in loures, portugal, the company has announced. Over the last 15 years, the technology has been used for the production of solid dispersions and is the fastest growing platform to overcome the solubility issues related to oral drugs, it is also relevant to inhalable particles, specialty excipients and for the isolation of thermally labile products.
This is the preferred method of drying of many thermallysensitive materials such as foods and pharmaceuticals. Furthermore, it conserves resources and environment due to its functional principle. Jul 06, 2015 a largescale spray drying unit specifically designed to handle high potency apis and for use with a wide variety of organic solvent systems is to be installed at hovione s new spray drying facility in loures, portugal. Spray drying of pharmaceuticals institution of engineers of. It is designed to visualize your spray drying process for wide range of applications in various fields such as pharma, materials, chemistry, food, feed, beverages, etc. Jul 06, 2015 hovione installs new largescale spray drying unit. Hovione, a portuguese company that develops active pharmaceutical ingredients apis and intermediates, is installing a new largescale spray drying unit at its plant in loures, portugal.
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